副猪嗜血杆菌抗原性研究进展

Progress on Antigenicity of Haemophilus parasuis

副猪嗜血杆菌是猪格拉瑟氏病的病原,主要引起SPF猪和断奶前后仔猪的纤维素性多发性浆膜炎、多发性关节炎和脑膜炎等。其抗原主要有荚膜、脂多糖和外膜蛋白等,不是所有的菌株都存在荚膜抗原,外膜蛋白抗原是刺激机体产生体液免疫的主要抗原,菌株抗原性的高低与毒力的强弱呈正相关,副猪嗜血杆菌的毒力因子至今仍不清楚,推测其荚膜、外膜蛋白、菌体细胞膜表面的自动传输三聚体蛋白等与副猪嗜血杆菌的毒力有关。至今已经定型的副猪嗜血杆菌有15个血清型,还有约30%为未定型的菌株,其中血清5型副猪嗜血杆菌为强毒力代表菌株,常作为研究副猪嗜血杆菌抗原性的代表菌株。副猪嗜血杆菌抗原性的深入研究必将为新型、高效疫苗的研究奠定坚实的基础。

Haemophilus parasuis（HPS） is the aetiological agent of Glasser＇s disease,which is responsible for cases of fibrinous polyserositis,polyarthritis,and mengingitis in SPF or before and post weaning young pigs.It mainly has capsule antigen,lipopolysaccharide and outer membrane protein antigens,however,not all HPS strains have capsule antigen,and outer membrane proteins are the major antigens which stimulate the immune system mainly producing humoral immune reactions.The antigenicity of HPS is correlated to its virulence,the higher virulence the higher antigenicity.Although HPS virulent factors are still unclear,they were supposed that its capsule,outer membrane proteins and trimeric autotransporters（a family of surface exposed proteins） are related to its virulence.Up to now,there are 15 serotypes identified with still about 30% isolates unable to be serotyped.HPS serotype 5 is the standard high virulent strain which is used to research HPS antigenicity.Deep research in HPS antigenicity should provide strong bases for new and highly efficient vaccine.