摘要
为筛选抗乙型肝炎病毒中药复方,通过肝切片方法来探索D-半乳糖胺(D-GalN)和刀豆蛋白(ConA)对小鼠肝脏的影响,提示腹腔注射D-半乳糖胺(1.8 g/kg)1 mL和尾静脉注射ConA(8 mg/mL)0.5mL与乙型肝炎病毒对肝脏的损伤程度类似,该两种药物可制作经济、有效的肝损伤模型。
In order to screen compound Chinese medicines against hepatitis virus B,the effects of D-GalN and ConA on the liver of mice were studies by observation of hepatic sections.The results showed that D-Ga1N（0.8 g/kg） 0.5 mL administrated peritoneally and ConA（3 mg/mL） 0.1 mL administrated through caudal vein achieved the same liver injury as hepatitis virus B.D-Ga1N and ConA can be used for the preparation of liver injury model.
出处
《动物医学进展》
CSCD
北大核心
2010年第7期121-123,共3页
Progress In Veterinary Medicine
基金
山东省教育厅基金资助项目(J07WJ53)
