黄芪抗氧化部位及其与三七总皂甙配伍组分对动脉粥样硬化的改善

Effects of Antioxidant Part of Astragali Radix and Its Combination with Panax notoginseng saponins on Atherosclerosis

用油脂稳定性指数(oil stability index,OSI)法筛选确定了黄芪乙酸乙酯抗氧化活性部位,并以高酯饲料喂养鹌鹑造动脉粥样硬化(atherosclerosis,AS)模型,考察黄芪抗氧化活性组分及其与三七总皂甙(PNS)配伍组分对实验性动脉粥样硬化的影响.给药8周,检测血清总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、总抗氧化能力(T-AOC)、超氧化物歧化酶(SOD)、丙二醛(MDA)含量.结果表明,黄芪抗氧化活性组分及其与PNS的配伍组分可显著降低(P<0.1)血清TC,TG,LDL-C,TC/HDL-C系数和MDA,升高血清HDL-C及T-AOC,SOD水平,对高脂胆固醇鹌鹑动脉粥样硬化具有很好的改善作用.

Antioxidant part of Astragali Radix was determined with an oil stability index（OSI） method.An experimental atherosclerosis in quails was established to observe the effects of the antioxidant part of Astragali Radix and its combination with Panax notoginseng saponins（PNS）.After 8 weeks of feeding with the antioxidant part of Astragali Radix and its combination with PNS,the total cholesterol（TC）,triglyceride（TG）,low density lipoprotein（LDL-C）,high density lipoprotein（HDL-C）,total antioxidant capacity（T-AOC）,superoxide dismutase（SOD）,and malondialdehyde（MDA） in serum were measured.The results show that,compared with atherosclerosis（AS） model quails,the serum TG,TC,LDL-C,MDA are obviously lower（P0.1） while T-AOC,SOD are totally opposite,indicating that the antioxidant part of Astragali Radix and its combination with PNS have good effects in anti-AS.