三维适形放射治疗局部复发鼻咽癌的疗效分析

Analysis on the Treatment Effect of Recurrent Nasopharyngeal Carcinoma with Three-dimensional Conformal Radiotherapy

【目的]探讨三维适形放射治疗局部复发鼻咽癌的临床效果。【方法】选择46例局部复发鼻咽癌患者，采用三维适形放射治疗技术，照射方法5～6Gy／次，每周5次，总量DT60～70Gy／10～14次．观察患者近期疗效，2年生存率和放射并发症。【结果】全部病例经三维适形放疗结束后1个月进行复查，显示完全缓解26例，占56．52％；部分缓解14例，占30．43％．总缓解率为86．96％。2年生存率69．57％，靶区局部控制率为92．17％。1例出现口腔炎症。【结论】三维适形放射治疗鼻咽部局部复发有较好的近期疗效和生存率，且放射损伤较低。

[ObjectivelTo explore the treatment effect of recurrent nasopharyngeal carcinoma （NPC） with three-dimensional eonformal radiotherapy （3DCRT）. [Methods] Forty six cases were selected to receive 3DCRT. The radiation regimen was 5 times each week with 4~5Gy per time, once a day, and the total dose was 60~70Gy for 10~ 14 times. The short-term efficacy, 2-years survival rate and radiation complications were observed. [Results]One month after 3DCRT, the reexamination was done for all patients. The results showed that complete remission rate was 56.52^（26/46）, partial remission rate was 30.43%（14/46）, the to tal remission rate was 86. 96%, the 2-year survival rate was 69.57% and the local control rate in target area was 92.17%. But one case was dead and one case had oral inflammation. [Conclusion] 3DCRT for the treatment of the recurrent NPC patients has better short term efficacy and survival rate. It also has less radiation injury.