期刊文献+

神经元环路中主神经元的模型分析 被引量:1

MODEL ANALYSIS OF PRINCIPAL NEURONS IN NEURAL CIRCUIT
下载PDF
导出
摘要 神经元环路是大脑神经系统的基本单元,而环路的信息输出则由主神经元所决定.本文通过对小脑皮层、嗅球和海马CA1三类不同环路中的主神经元:浦肯野神经元、僧帽神经元和锥体神经元建立给予神经元几何形态和电缆传递的多房室模型,通过它们的动作电位分析和比较,说明不同类型的外界刺激,三个环路中主神经元动作电位的区别;并进一步比较对同类刺激,三类主神经元动作电位的不同,模型验证它们所属环路在神经系统中所起的不同输出功能. Based on the neural morphology and multicompartment model,this paper constructed the corresponding compartment models of cerebellar cortex purkinje neuron,olfactory bulb mitral neuron and hippocampus CA1 pyramidal neuron.By analyzing the action potential,the different action potentials of the three neural circuit's principal neurons under different types of external stimuli were illustrated.For the same type of external stimuli,the action potential of the three different neural circuit's principal neurons were also illustrated.The model results verify that the three different neural circuits have different output functions in their nervous system.
作者 汪雷 刘深泉
出处 《动力学与控制学报》 2010年第2期146-150,共5页 Journal of Dynamics and Control
基金 国家自然科学基金资助项目(10872069)~~
关键词 浦肯野神经元 僧帽神经元 CA1锥体神经元 动作电位 房室模型 purkinje neuron mitral neuron CA1 pyramidal neuron action potential compartment model
  • 相关文献

参考文献10

  • 1A.朗斯塔夫著,韩济生主译.神经科学(中译本).科学出版社,2006.
  • 2Jan Voogd, Mitchell Glickstein. The anatomy of the cerebellum. Trends Neuroscience, 1998, 21:370 - 375.
  • 3Daniel B Rubin, Thomas A CIeland. Dynamical mechanisms of odor processing in olfactory bulb mitral ceils. Journal of Neurophysilolgy,2006,96 : 555 - 568.
  • 4Michele Migliore, Gaspare Novara, Domenico Tegolo. Single neuron binding properties and the magical number 7. Hippocampus, 2008,18:1122 - 1130.
  • 5Tsugumichi Miyasho, Hiroshi Takagi, et al. Low - threshold potassium channels and a low - threshold calcium channel regulate Ca2 + spike firing in the dendrites of cerebelIar Purkinje neurons, a modeling study. Brain Research, 2001, 891:106 - 115.
  • 6Wei R. Chen, Wenhui Xiong, Gordon M. Shepherd. Analysis of relations between NMDA receptors and GABA release at olfactory bulb reciprocal synapses. Neuron, 2000, 25: 625 - 633.
  • 7Ted Camevale, Michael Hines. The Neuron Book. Cambridge University Press, 2006.
  • 8Mainen Z F, Sejnowski T J. Influence of dendritic structure on firing pattern in model neocortical neurons. Nature, 1996 ,25:382 (6589) :363 -6.
  • 9王海侠,陆启韶,郑艳红.神经元模型的复杂动力学:分岔与编码[J].动力学与控制学报,2009,7(4):293-296. 被引量:17
  • 10严传魁,刘深泉.海马结构中DG对CA3的信号传递作用[J].自然科学进展,2007,17(7):884-892. 被引量:3

二级参考文献23

  • 1王青云,陆启韶,王海侠.Transition to complete synchronization via near-synchronization in two coupled chaotic neurons[J].Chinese Physics B,2005,14(11):2189-2195. 被引量:16
  • 2Buzsa'ki G, Penttonen M, Bragin A, et al. Possible physiological role of the perforant path-CA1 projection. Hippocampus, 1995, 5(2): 141-146
  • 3Chrobak, J J, Buzsa'ki G. High frequency oscillations in the output network of the hippoeampal-entorhinal axis of the freely behaving rat. The Journalof Neuroseience, 1996, 16(9): 3056-3066
  • 4Frieker D, Verheugen JAH, Miles R. Cell-attached measurements of the firing threshold of rat hippoeampal neurones. Journal of Physiology, 1999, 517(3): 791-804
  • 5Ishizuka S, Hayashi H. Spontaneous epileptiform bursts and long-term potentiation in rat CA3 hippocampal slices induced by chaotic stimulation of mossy fibers. Brain Research, 1998, 790(1): 108-114
  • 6Traub RD, Wong RKS, Miles R, et al. A model of a CA3 hippocampal pyramidal neuron incorporating voltage-clamp data on intrinsic conductances. Journal of Neurophysiology, 1991, 66(2): 635-650
  • 7Ribar CE, Nitsch R, Seress L. Projection of paralbumin 2 positive basket Cell in the GABAergic innervation of pyramidal and granule cells of the rat hippocampal formation. J Comp Neurol, 1990, 330 (5): 4492-4561
  • 8Harris KM, Jensen FE, Tsao B. Three-dimensional structure of dendritic spines and synapses in the rat hippocampus (CA1) at postnatal day 15 and adult ages.. Implications for the maturation of synaptic physiology and long-term potentiation. J Neurosci, 1992, 12(12): 2685-2705
  • 9Traub RD. Simulation of intrinsic bursting in CA3 hippocampal neurons. Neuroscience, 1982, 7(5): 1233-1242
  • 10Traub RD, Jefferys JGR. Simulations of epileptiform activity in the hippocampal CA3 region in vitro. Hippocampus, 1994, 4 (3): 281-285

共引文献17

同被引文献8

引证文献1

二级引证文献1

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部