缩宫素联合钙剂和米索前列醇预防及治疗产后出血的临床分析

Clinical analysis of Oxytocin combined with Calcium preparation and Misoprostol for preventing and treating postpartum hemorrhage

目的探讨缩宫素联合钙剂和米索前列醇预防及治疗产后出血的临床效果。方法选取300例自然分娩产妇随机分成两组,实验组在宫口开全后,即用葡萄糖酸钙注射液静脉滴注,胎儿娩出后肌肉注射缩宫素20u,在胎盘娩出后予肛门纳入米索前列醇200μg;对照组在胎儿娩出后肌注缩宫素20u。结果实验组产后2小时及24小时出血量及产后出血率明显低于对照组,差异有统计学意义(P<0.05)。结论缩宫素联合钙剂和米索前列醇预防及治疗产后出血有明显疗效,值得临床推广。

Objective To study clinical effect of Oxytocin combined with Calcium preparation and Misoprostol for preventing and treating postpartum hemorrhage. Methods Three hundreds parturients with spontaneous delivery were divided into study group（n=150） and control group randomly（n=150）. Parturients in study group were administered Calcium preparation with intravenously guttae after cervical orifice opening completely and 20u Oxytocin with intramuscular injection,then Misoprostol put in the anus after placental expulsion. The other 150 cases in control group were only given 20^u Oxytocin. Results The difference was significant（P〈0.05） on the volume of postpartum hemorrhage of cases in 2-hour and 24-hour and postpartum bleeding rate between two groups. Conclusion Oxytocin combined with Calcium preparation and Misoprostol could reduce postpartum hemorrhage so that the method was worth wide clinical application.