p21和p16基因在早期食管癌中的表达

The Expression of p21 and p16 Gene in Human Early Esophageal Carcinoma

目的探讨p21和p16基因在食管癌发生中的作用及其相关性。方法应用免疫组织化学S-P法检测p21和p16基因在19例食管早期癌、20例异型增生以及10例正常食管黏膜标本中的表达。结果 p21和p16基因在早期癌中的表达均低于正常食管黏膜(P<0.05)。结论 p21和p16基因与食管癌的发生有关,他们的变化是食管癌发生中的早期事件。

Objective To study the effect of p21 and p16 Gene in esophageal carcinogenesis and their relationship.Methods Immunohistochemical S-P method was used to detect the expressions of p21 and p16 Gene in 19 cases of esophageal early carcinoma,20 cases of dysplasia and 10 cases of normal esophageal mucous.Results The expression of p21 and p16 Gene were both lower in early esophageal carcinoma than in normal esophageal mucous（P0.05）.Conclusion p21 and p16 Gene are related to esophageal carcinogenesis,and their changes are early events in esophageal carcinogenesis.