摘要
目的:探讨改进型实验性左侧精索静脉曲张(ELV)对大鼠血清卵泡刺激素(FSH)及抑制素B(InhB)的影响。方法:利用改进的方法建立青春期SD大鼠左精索静脉曲张的模型30只;假手术组SD大鼠30只作对照组。术后3个月,取大鼠血清,ELISA法分别检测FSH、InhB的浓度。结果:实验组大鼠血清中FSH浓度[(37.56±9.72)ng/ml]与对照组[(26.69±5.33)ng/ml]相比升高,具有统计学意义(P<0.05);而实验组大鼠血清中InhB的浓度[(349.93±99.48)pg/ml]与对照组[(768.83±146.96)pg/ml]相比下降,具有统计学意义(P<0.05)。结论:改进型ELV致FSH升高及InhB下降,这些变化可能是影响生育能力的机制之一。
Objective: To evaluate the effects of improved experimental left varicocele (ELV) on follicle-stimulating hormone (FSH) and inhibin B (InhB). Methods: ELV models were established by the improved method in 30 SD rats, and another 30 were included in a sham operation group as controls. Three months after the operation, the concentrations of the FSH and InhB were assayed by ELISA. Results : The concentration of FSH in the serum was significantly higher in the experimental group ( [ 37.56 ±9.72 ] ng/ml) than in the control ( [26.69 ± 5.331 ng/ml) (P 〈0.05), while that of InhB significantly lower in the former ( [349.93 ±99.48 ] pg/ml) than in the latter ( [ 768.83± 146.96 ] pg/ml) ( P 〈 0.05 ). Conclusion : Improved ELV can increase FSH and reduce InhB in rats, which may be associated with subfertility.
出处
《中华男科学杂志》
CAS
CSCD
北大核心
2010年第6期495-497,共3页
National Journal of Andrology
基金
上海市科委科研计划资助项目(08140902000)~~