前列腺癌标志物研究进展

An update of the markers for prostate cancer

前列腺癌是男性泌尿系统常见的恶性肿瘤之一,近年来其发病率在我国呈上升趋势。前列腺癌的最常用检测标志物就是前列腺特异性抗原(PSA),随着人们对PSA的不断认识,逐渐发现PSA的组织特异性较高,而癌特异性较差,其临床应用价值也有待重新评估,因此大量研究转向寻找新的前列腺癌标志物,目前已取得不少成果。本文从DNA、RNA和蛋白质水平三方面阐述前列腺癌标志物的研究进展,以期为前列腺癌的诊断和治疗提供新途径。

Prostate cancer is one of the most familiar malignancies in the male urinary system, and its incidence is on the rise in China in recent years. As a most commonly used marker for prostate cancer detection, prostate-specific antigen （PSA） has a high organic but a low carcinomatous specificity, and its clinical application value needs to be reestimated. Many studies have been devoted to the finding of new market＇s for prostate cancer and some achievements already obtained. This article approaches the markers for prostate cancer in three aspects, DNA, RNA and protein, hoping to offer a new insight into the diagnosis and treatment of prostate cancer.