他达拉非独特的时间顾虑收益

Benefits of tadalafil in sexual activity-related time concerns

社会心理因素在勃起功能障碍(ED)的发病过程中占到了十分重要的地位。一种理想的治疗药物应能给患者及其伴侣带来满意的社会心理收益。"心理与人际关系量表"(PAIRS量表)既能评价ED对患者及其伴侣的心理及人际关系影响,又能预测ED患者对治疗的满意度。利用PAIRS量表对5型磷酸二酯酶(phosphodies-terasetype5,PDE5)抑制剂治疗ED的疗效进行评估,发现在降低ED患者性活动相关性时间顾虑方面,他达拉非明显优于西地那非和伐地那非。这也正是ED患者及其伴侣在临床治疗条件下偏好使用他达拉非的深层原因。与此相关的药物属性则是他达拉非长达36h的卓越疗效。

Sociopsychological factors play a critical role in the pathogenesis of erectile dysfunction （ED）. An optimal therapeutic regimen is supposed to bring sociopsychologieal benefits to both the patients and their partners. Psychological and Interpersonal Relationship Scales （PAIRS） is an effective measure for evaluating the impact of ED on the psychological aspects and interpersonal relationship of the patients and their partners, as well as for predicting the satisfaction of ED patients with the treatment. PAIRS scores on the effects of phosphodiesterase type 5 inhibitors on ED show a significant decrease in sexual activity-related time concerns of the patients treated with tadalafil, as compared with those medicated with sildenafil or vardenafil. This also underlies the preference of the patients and their partners for tadalafil in clinical practice. The drug attribute associated with the decreased time concerns is the long and outstanding efficacy of tadalafil for up to 36 hours.