ACEI对过量饮酒大鼠心脏的保护作用

Protective effect of ACEI on cardiac structure and function in excessive alcohol-consumption rats

目的研究血管紧张素转化酶抑制剂(ACEI)对过量饮酒大鼠心脏功能和结构的保护作用。方法 30只大鼠随机分为对照组、酒精组和ACEI组,每组10只。酒精灌胃建立动物模型,并给予ACEI类药物作为保护剂,用超声心动图及超微病理技术观察大鼠心脏功能和结构改变。结果酒精组左室舒张末期内径高于对照组[(6.86±0.64)mmvs(6.29±0.28)mm,P<0.05],收缩末期内径高于对照组[(3.45±0.32)mmvs(2.95±0.25)mm,P<0.05];两组收缩功能参数左室射血分数、每搏输出量、短轴缩短率无统计学差异(P>0.05);舒张功能参数二尖瓣内环舒张早期晚期速度比(Ea/Aa)低于对照组[(0.642±0.126)vs(1.276±0.083),P<0.05]。而ACEI组各参数相对于对照组没有明显改变(P>0.05)。病理形态学观察可见,酒精组线粒体水肿、嵴和膜大部分溶解消失。ACEI组线粒体少部分嵴和膜溶解,损伤程度较酒精组轻。结论 ACEI类药物对过量饮酒大鼠的心肌具有一定的保护作用。

Objective To investigate the protective effect of （ACEI） on cardiac function and structure in excessive alcohol-consumption rats. Methods 30 rats were randomly divided into three groups：the control group,the alcohol group and the ACEI group,10 for each group. They were arranged for intragastric administration of alcohol,and given ACEI as a protector. Then echocardiography and an ultrastructural exam were performed to assess cardiac dysfunctions. Results The left ventricular end-diastolic dimension （LVEDd） and left ventricular end-systolic dimension （LVEDs） were increased in the alcohol group [LVEDd（6.86±0.64） mm,LVEDs（3.45±0.32）mm]compared with those in the control group [LVEDd（6.29±0.28） mm,LVEDs（2.95±0.25）mm]（P0.05）. Between the two groups,there were no significant differences in systolic LV function factors（P0.05）,such as ejection fraction,fractional shortening and stroke volume,but the diastolic function factor Ea/Aa decreased in the alcohol group （0.642±0.126） compared with the control group （1.276±0.083）,P0.05]. However,there was no significant difference between the ACEI group and the control group （P0.05）. It was shown on ultra-structure that cardiac cells in the alcohol group presented mitochondrial swelling,hydropic change,and most of the cristae disappeared,while cells in the ACEI group showed less damage to mitochondria. Conclusion ACEI can protect the cardiac myocyte from the injury of over alcohol consumption.