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曲格列酮对胰岛β细胞胰岛素分泌的影响及机制研究 被引量:1

Effect of troglitazone on insulin secretion in pancreatic β-cells and its mechanism
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摘要 研究曲格列酮对胰岛β细胞(MIN6细胞株)胰岛素分泌的影响,并探讨其机制.10μmol/L曲格列酮短期抑制大鼠胰岛和MIN6细胞的葡萄糖刺激的胰岛素分泌(GSIS,P〈0.01),增加AMP活化的蛋白激酶(AMPK)、乙酰辅酶A羧化酶(ACC)的磷酸化水平(均P〈0.01),而AMPK抑制剂复合物C可使其AMPK、ACC的磷酸化水平以及胰岛素分泌完全恢复. The effect of troglitazone on glucose-stimulated insulin secretion (GSIS) in pancreatic β-cells and its mechanism were investigated.10 μmol/L troglitazone had no effect on basal insulin secretion,but significantly decreased GSIS and stimulated AMP-activated protein kinase (AMPK) and acetyl-CoA carboxylase (ACC) phosphorylations (all P〈0.01).These reactions were completely reversed by AMPK inhibitor compound C,suggesting that the troglitazone acutely inhibits insulin secretion via stimulating AMPK activity in beta cells.
出处 《中华内分泌代谢杂志》 CAS CSCD 北大核心 2010年第6期493-495,共3页 Chinese Journal of Endocrinology and Metabolism
基金 国家自然科学基金资助项目(30700382,30771021) 葛兰素史克公司资助项目A^+前沿基金
关键词 曲格列酮 葡萄糖刺激的胰岛素分泌 AMP活化的蛋白激酶 Troglitazone Glucose-stimulated insulin secretion AMP-activated protein kinase
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