固体超强酸ZrO_2-SO_4^(2-)催化合成核黄素四乙酸酯

Synthesis of Riboflavin Tetraacetate by Solid Superacid ZrO_2 - SO_4^(2-)

对固体超强酸ＺｒＯ_２－ＳＯ_４^（２－）催化合成核黄素四乙酸酯进行了研究。核黄素与乙酸酐摩尔比１：４０，催化剂用量为反应物总质量的８．０％，反应温度８０℃，反应时间２．５ｈ，核黄素四乙酸酯产率可达７６．９％。ＺｒＯ_２ＳＯ_４~￣（２-）催化活性高于ＴｉＯ_２－ＳＯ_４^（２－）和Ｆｅ_２Ｏ_３－，ＳＯ_４^（２－）ＺｒＯ_２在１ｍｏｌ／ＬＨ_２ ＳＯ_４中浸渍 ２４ｈ，６００℃焙烧 ３ｈ催化活性最高。

The riboflavin tetraacetate was synthesized starting from riboflavin and acetic anhydride, and the solid superacid ZrO_2- SO_4^(2-) as catalyst. The yield of riboflavin tetraacetate reached up to 76. 9% by slowly adding 0. 01mol (3. 76g) riboflavin to 4g (8% of system loud mass) solid superacid ZrO_2 - SO_4^(2-) in 0. 4mol (40. 8g) acetic anhydride and stirring for 2. 5 hours at 80. The solid superacid catalyst ZrO_2 - SO_4^(2-) was synthesized by adding 4. 0g ZrO_2 to 30ml 1mol/L H_2SO_4, immersing 24 hours at 30, baking 3 hours at 600.