神经激肽1受体拮抗剂研究进展

Neurokinin-1 receptor antagonists:research advances

神经激肽中P物质是中枢神经系统最重要的神经递质之一,通过与其受体,如神经激肽1受体(NK1R)结合在多种疾病的病理过程中发挥作用。NK1R拮抗剂近年来在临床上应用广泛,不仅能够缓解抑郁、焦虑的症状,而且对抑郁症、焦虑症和化疗引起的恶心、呕吐具有很好的疗效。本文就近年来NK1R拮抗剂的研究进展进行综述。

Substance P is one of the most important neurotransmitter in the nervous system. It plays an important role in the pathological process of many diseases through combineing with its receptors,for example,neurokinin-1 receptor （NK1R）. The antagonists of NK1R（NK1RA） that are widely used in recent clinical treatments can not only relieve deppression and anxiety,but also have good antiemetic effects on chemotherapy-induced nausea and vomiting. In this review,the relevant study results in this field in recent years are described.