加替沙星治疗急性下呼吸道细菌感染的研究

Treatment of acute lower respiratory tract bacterial infection by gatifloxacin

目的：研究加替沙星序贯疗法治疗急性下呼吸道细菌感染的疗效和安全性。方法：对46例急性下呼吸道细菌感染患者,采用加替沙星0.2g,bid,6-8d静脉滴注,继之以0.4g,qd,4-7d,口服。结果：痊愈14例（30.43%）,显效28例（60.87%）,改善4例（8.70%）,总有效率为91.30%,细菌消除率为95.66%,总疗程为10-15d,平均（12.0±2.7）d,药物副作用较少,发生率为2.17%。结论：加替沙星序贯疗法治疗急性下呼吸道细菌性感染有效、安全。

Objective： To study the efficacy and safety of gatifloxacin in the treatment of acute lower respiratory tract bacterial infection （ALRTBI）by sequential therapy. Methods： Forty six patients with ALRTBI were treated with gatifloxacin iv drip in a regimen of 0.2 g bid for 6-8 d then with oral gatifloxacin dose of 0.4 g qd for 4-7 d in sequence. Results： An effective rate was 91.30% and a bacterial eradication rate was 95.66%, the tolerable side effect was 2.17%. Conclusion： Gatifloxacin sequential therapy is an effective and safe agent for treatment of acute lower respiratory tract bacterial infection.