膨胀床吸附层析及其在生化分离中的应用

Expanded Bed Adsorption Chromatography And Its Application in Bioseparation

膨胀床是稳定无返混的流化床，它可直接从料液中吸附目标产物，不需预先除去料液中的颗粒。膨胀床将料液的澄清、浓缩和初步纯化集成于一个单元操作中，大大降低了分离过程的复杂程度，提高分离效率。吸附剂的物性、膨胀床装置、料液的性质以及操作条件等因素对膨胀床的稳定和分离效率有很大的影响。

An Expanded bed is a stable fluidized bed which has no backmixing.It can capture product directly from the crude feed without the removal of solid particles.The process steps of clarification,concentration and initial purification can be combined into one unit operation,providing increased separation efficiency and reduced the complexity of separation process.The critical factors which affect the stability and separation efficiency include the physical properties of adsorbent,the equipment of expanded bed,feed characteristics and the operating conditions.