咖啡酸片在肺癌化疗中对骨髓保护作用的临床观察

目的观察评价咖啡酸片在预防非小细胞肺癌（NSCLC）患者术后辅助化疗中对骨髓抑制的影响。方法52例非小细胞肺癌患者随机分为观察组和对照组，观察组（36例）采用咖啡酸片加Pc（Paclitaxel＋Carboplatin）方案治疗，对照组（36例）采用PC方案化疗，观察二者骨髓抑制程度及集落刺激因子用量。结果观察组Ⅱ度及Ⅲ度骨髓抑制发生率显著低于对照组（P〈0．05）；应用集落刺激因子均能使化疗后白细胞下降的患者白细胞上升至正常范围（〉4×109／L）。但观察组和对照组白细胞升至正常范围的时间平均为（3．68±0．51）天和（5．12±0．82）天，观察组、对照组人均集落刺激因子（150μg）用量分别为（3．28±1．13）支和（5．36±0．54）支，差异有显著性（P〈0．05）。结论咖啡酸片升高白细胞的作用显著，可有效预防并减轻老年非小细胞肺癌患者术后辅助化疗中的骨髓抑制，明显提高患者的化疗耐受性。

Objective： To observe the effects of Kafeisuan tablet on leucocyte decreasing in chemotherrpy of non-small cell lung cancer （NSCLC） . Methods： 52 patients of NSCLC were randomized into two groups： observational group （36 patients, PC＋ Kafeisuan tablet）, control group （36 patients, PC only）. To investigate the medullary inhibition level and the quantity of colony stimulating factor being used. Results： The rate of Ⅱ and Ⅲ medullary inhibition in observational group is significant lower than in control group （P〈 0.05） . The colony stimulating factor could turn the down leucocyt up to snuff （〉4× 109/L） . It took average 3.5 and 5 days in observational group and control group respectively. The quantity of colony stimulating factor （1501xg） being used in observational group and control group were 3.28±1.13 and 5.36±0.54 respectively and it had a significant difference with P〈 0.05. Conclusion： Kafeisuan tablet is better in the chemotherapy of NSCLC by decerasing the medullary inhibition, improving the down lcucocyt and reducing the risk of chemotherapy. Kafeisuan tablet has a better effect and low price and can be used together with colony stimulating factor in clinic.