46例小儿巨细胞病毒肺炎的临床分析

目的探讨小儿巨细胞病毒(CMV)肺炎的临床特点、实验室检查及更昔洛韦的临床疗效。方法对46例小儿巨细胞病毒肺炎的临床资料进行回顾性分析。结果小儿巨细胞病毒肺炎以小婴儿发病多见,多以咳喘(89.1%)为首发症状,且病程较长,病情较重,多为间质性肺炎,常合并肺外表现,尿荧光定量聚合酶链反应阳性。46例均给与更昔洛韦治疗后,35例(76.1%)治愈,11例(23.9%)好转。结论荧光定量聚合酶链反应检测尿液巨细胞病毒简单方便,具有高灵敏性;更昔洛韦治疗小儿CMV巨细胞病毒肺炎疗效满意。

Objective To explore the clinical features, laboratory examination of cytomegalovirus （CMV） pneumonia in children, and the clinical efficacy of ganciclovir in treating CMV pneumonia.Methods Retrospectively analyzed the clinical data of 46 cases of CMV pneumonia in children.Results Cytomegalovirus pneumonia disease happened in small babies much more, and cough and asthma（89.1%） is the first symptom. CMV pneumonia’ course of the disease was long and the condition was serious, most of which were interstitial pneumonia. Fluorescence quantitative polymerase chain reaction of urine was positive. 46 cases were given treatment with ganciclovir, 35 cases （76.1%） cured and 11 cases （23.9%） improved.Conclusion The fluorescence quantitative polymerase chain reaction for detection of urine Cytomegalovirus is simple and convenient,with high sensitivity. Treating CMV pneumonia in children with Ganciclovir,the results were satisfactory.