P-糖蛋白在肺癌中的表达

EXPRESSION OF P-GLYCOPROTEIN IN LUNG CANCERS

采用C219免疫组织化学染色方法（ABC法），检测P－gp在33例肺癌中的表达，在16例腺癌中，P－gp表达阳性者10例，阳性率为62．5％，14例磷癌中，P－gp表达阳性者2例，阳性率为14．29％，3例小细胞肺癌中．P－gp表达均阴性。腺癌中P－gp表达阳性率显著高于磷癌和小细胞肺癌，提示P－gp表达是肺癌产生内在抗药性的机制之一。

P-glycoprotein(P-gp) expression was tested in 33 cases of lung cancers by C219 immunohistochemistry decoration method(by ABC method).The results showed that P-gp was detected in 10 of 16 cases of adenocarcinomas, the positive rate was 62.5 %, and P-gp was detected in 2 of 14 cases of squamous cell carcinomas, the positive rate was 14. 29 %, and P - gp was negative in all 3 cases of small-cell lung cancers. The positive rate of P - gp expression in lung adenocarcinomas was significantly higher than that of squamous cell carcinomas and small-cell lung cancers, it is suggested that P - gp expression might be one of the reasons of intrinsic multidrug-resistance of lung cancers.