冠状动脉慢血流相关因素分析

Analysis of correlation factors of slow coronary flow

目的:探讨与冠状动脉慢血流(SCF)现象相关的危险因素。方法:回顾性分析2005年8月至2008年12月我院行冠状动脉造影显示心外膜主要冠状动脉无明显病变的病例,共186例的资料。以冠脉血流≤TIMI2级的为SCF患者,被分为SCF组(96例),TIMI3级者为对照组(90例)。结果:SCF组的人体质量指数[(27.06±3.40)kg/m2:(25.53±3.57)kg/m2];红细胞压积[(0.43±0.07):(0.41±0.04)],凝血酶时间[(18.23±2.80)s:(17.33±1.73)s],白细胞计数[(6.65±1.73)×109/L:(6.05±1.56)×109/L]均明显高于对照组(P均<0.05)。高密度脂蛋白-胆固醇明显低于对照组[(1.12±0.28)mmol/L:(1.21±0.29)mmol/L,P<0.05]。Logistic分析表明,BMI(OR1.373,95%CI1.146～1.645,P=0.001)、凝血酶时间(OR1.348,95%CI1.056～1.722,P=0.017)、白细胞计数(OR1.920,95%CI1.234～2.987,P=0.004)是发生SCF的危险因素。结论:体质指数、凝血酶时间、白细胞计数增高可能是促进冠状动脉慢血流发生的危险因素。

Objective： To analyze the correlation factors of slow coronary （low （SCF） retrospectively. Methods： The study population included 186 patients with angiography proven, their coronary arteries were normal. Coronary flow was determined by thrombolysis in myocardial infarction （TIMI） flow grade. Patients who belonged to ≤TIMI 2 were included in SCF group （n=96） and belonged to TIMI 3 were included in control group （n=90）. Results： Body mass index [ （27.06±3.40） kg/m^2 vs. （25.53±3.57） kg/m^2], hematocrit [ （0.43±0.07） vs. （0.41±0.04）], thrombin time [ （18.23±2.80） s vs. （17.33±1.73） s], number of white blood cell [ （6.65±1.73）×10^9/L vs. （6.05×1.56） ×10^9/L] were significantly higher in SCF group compared with the control group respectively, P〈 0.05 all. But HDL-C level was significantly lower in SCF group than that of control group [ （1. 1220.28） mmol/L vs. （1 . 2120. 29） mmo l /L, P〈0. 05]. Logistic regression test suggest that, body mass index （OR 1. 373, 95% C1 1.146-1. 645, P=0.001）, thrombin time （OR 1.348, 95% CI 1. 056-1. 722, P=0.017）, white blood cell （OR 1. 920, 95% CI 1. 234-2. 987, P= 0. 004） were the risk factors of slow coronary flow. Conclusions： Body mass index, thrombin time, and number of white blood cell increase may be the risk factors of slow coronary flow.