摘要
综述我国创制的抗疟新药青蒿琥酯的药理与临床应用进展。青蒿琥酯给药后在体内血浆中的浓度远大于体外对恶性疟原虫的最小抑制浓度；临床上清除疟原虫９５％所需时间仅为１６小时；临床应用数千例未见明显的毒副作用；可通过口服、静注、肌注及直肠等多种途径给药；青蒿琥酯的半衰期短，可能有利于延迟抗药性的产生。该药已成为对恶性疟有快速治疗效果且耐受性好的抗疟药，现已在亚、非、拉等疟疾流行区被广泛用于治疗各种疟疾。
New antimalarial artesunate was invented in our country. This article summarized the pharmacological effect and clinical application of this drug. Peak plasma concentration of artesunate in vivo is greater than the minimal inhibitory concentration against p.falciparum in vitro. this drug can eliminate 95% of plasmodium from body within 16 hours.No obvious toxic or side effects were observed. It can be given per os,iv,im or rectum.The short half life of it may be favorable for delaying the producing of the drug resistance.Artesunate has quick effciency for p. falciparum and is well tolerabled.The drug is widely used to treat various malaria of malaria epidamic areas in Asia,Afica and Latin America.It is an ideal drug for the treatment of cerebral malaria or other severe p.falciparum.
出处
《药学进展》
CAS
1999年第1期46-52,共7页
Progress in Pharmaceutical Sciences
