SBHL对S180荷瘤小鼠肿瘤生长及免疫功能的影响

The effect of SBHL on the tumor growth and immune functions in S180-bearing mice

目的探讨SBHL对肿瘤的作用效果及其抗肿瘤免疫效应机制。方法选用S180荷瘤小鼠,采用腹腔注射SBHL[103、0、50 mg/(kg.d)],连续注射10 d,观察肿瘤生长及SBHL对小鼠免疫功能的影响。结果 SBHL能显著抑制荷瘤小鼠S180肉瘤的生长。SBHL对荷瘤小鼠受抑的细胞免疫功能具有明显正向调节作用,能提高T淋巴细胞增殖及IL-2产生能力,增强NK和LAK细胞活性。结论 SBHL能明显抑制肿瘤的生长,SBHL的免疫增强效应可能是其发挥抗肿瘤作用的重要途径。

Objective In order to investigate the antitumor effect of SBHL and its immunological mechanisms. Methods The S180-bearing mice were treated with SBHL （ 10,30,50 mg/kg, d） and 10 days later to observe the effect of SBHL on the tumor growth and the immunological functions in tumor-bearing mice. Results SBHL inhibited the growth of S180 sarcoma significantly and pro- mote the lymphocytic proliferation and IL-2 producing ability of spleen cells in S180-bearing mice. SBHL enhanced significantly the activities of NK cells and LAK cells in tumor-bearing mice. Conclusion These results suggested that SBHL could obviously inhibit the growth of tumor in mice and the antitumor effect of SBHL might be mediated by inducing the antitumor immunity of the host.