液相可控沉淀技术制备纳微结构药物颗粒

Review of liquid controlled precipitation process for preparation of pharmaceutical nano-/microparticles

纳米药物作为纳米技术与医药技术的重要组成部分,受到了全世界学术界和产业界的重视。药物纳米化工程及应用是研究的热点问题。本文总结了液相沉淀法制备纳微结构药物颗粒的基本原理和方法,综述了近年来本课题组在药物构型的密度泛函计算以及液相沉淀法制备纳微结构药物颗粒方面的学术和产业化成果。针对不同药物体系的特性,提出了采用反溶剂沉淀法、反应沉淀法、反溶剂与反应耦合沉淀法以及分子自组装沉淀法等来制备纳微结构药物颗粒,阐述了超重力可控沉淀技术在制备纳微结构药物颗粒方面的工业化应用前景。

As an important component of nano-technology and medical technology,nano drug has continuously attracted enormous interest from all over the world both in academic and industrial fields. Engineering and application of pharmaceutical nanoparticles is the primary focus of numerous research groups.This paper summarized the basic principles and preparation methods of nano-/micro-structured drug particles,and reviewed DFT calculation results of pharmaceutical conformers,as well as the academic and industrial achievements of preparing nano-/micro-structured drug particles via liquid-phase precipitation method by authors＇ research group.For different characteristics of drug systems,anti-solvent,reaction,anti-solvent coupled reaction precipitation,and molecular self-assembly precipitation method were successfully developed for the preparation of nano-/microstructured drug particles.The industrial applications of high-gravity controlled precipitation technology in the preparation of nano drug were also addressed.