美沙拉嗪栓治疗溃疡性结肠炎28例临床疗效观察

Clinical effect of mesalazine suppository in the treatment of 28 cases with ulcerative colitis

目的:观察美沙拉嗪栓治疗溃疡性结肠炎(UC)的临床疗效。方法:选择56例轻、中度溃疡性结肠炎患者,随机分为两组:实验组28例,予美沙拉嗪栓塞肛,1枚/次,1次/d;对照组28例,予口服柳氮磺吡啶片(Alicylazosulfapyridine,SASP)1.0g,4次/d口服。疗程为8周。结果:美沙拉嗪栓塞肛治疗UC比口服SASP效果明显。实验组治疗过程中不良反应的发生率明显低于对照组。结论:在轻、中度溃疡性结肠炎治疗中,美沙拉嗪栓塞肛治疗UC临床疗效优于口服柳氮磺吡啶片,且不良反应少。

Objective To observe the clinic effect of mesalazine suppository in treating ulcerative colitis.Method For 56 cases of mild or moderate ulcerative colitis were randomly divided into two groups,the therapy group（n = 28） was given mesalazine suppository by anal pluging（one tablet per day） and the control group（n = 28） was given alicylazosulfapyridine（SASP）（1.0 g,4 times per day,oral taken）.The treatment period lasted 8 weeks.Results Mesalazine suppository given by anal pluging showed better effects than SASP in treating ulcerative colitis,with fewer side effects.Conclusion Mesalazine suppository given by anal pluging shows better effects and less side effects than alicylazosulfapyridine in treating mild or moderate ulcerative colitis.