中西结合治疗慢性重型肝炎血小板聚集功能观察

Observation of Platelet Agglutination in Treatment of 35 Cases of Chronic Severe Hepatitis

目的：观察中西医结合治疗慢性重型肝炎３５例，治疗前后血小板聚集功能的变化。方法：在西药综合治疗的基础上，将３５例慢性重型肝炎分肝肾阴虚、肝郁脾虚、湿热蕴结３型辨证施治，并设单纯西药治疗２４例作对照。结果：中西结合治疗组总有效率明显优于单纯西药对照组（Ｐ＜０．０５）；治疗组早期治疗后ＰＡＧ值显著升高，与治疗前及对照组相比有非常显著性差异（Ｐ＜０．０１），中期治疗后ＰＡＧ升高与治疗前比较有显著性差异（Ｐ＜０．０５），但与对照组相比无明显差异（Ｐ＞０．０５）。结论：ＰＡＧ是慢重肝的可靠诊断指标之一，对观察疗效、判断预后有重要的临床意义。

OBJECTIVE:To observe changes in platelet agglutination before and after treatment of 35 cases of chronic severe hepatitis with both western medicine and TCM.METHOD:The 35 patients were divided into 3 types,namely,the type of deficiency of yin in the liver and kidney,the type of liver depression and spleen deficiency,and the type of accumulation of damp-heat,compared with a control group of 24 patients treated simply with western medicine.RESULT:The therapeatic effect obtained in the treatment group was markedly more satisfactory than in the control group( P <0.05).During the early period of the treatment PAG in the treatment group rose significantly,with marked difference as compared with the control group( P <0.01).During the middle period,PAG also rose greatly compared with that before the treatment( P <0.05),but with no marked difference compared with the control group( P >0.05).CONCLUSION:PAG is one of the important criteria for the diagnosis of chronic severe hepatitis In treating this disease,it is advisable to use both wester medicine and traditional Chinese medicine.