摘要
采用ＭＴＴ比色法检测了青年妇女、围绝经妇女及绝经后妇女的血清ＩＬ６活性、血清Ｅ２水平及Ｌ２－４骨密度（ＢＭＤ）值。结果：绝经后妇女血清ＩＬ６活性明显升高，ＢＭＤ值显著低于青年妇女与围绝经妇女（Ｐ＜００１），血清Ｅ２水平也显著低于青年妇女与围绝经妇女（Ｐ＜００１）。相关分析显示：ＩＬ６与ＢＭＤ呈负相关（Ｐ＜００５），与Ｅ２呈负相关（Ｐ＜００１）；Ｅ２与ＢＭＤ呈正相关（ｒ＝０６６０，Ｐ＜００１）。结果表明，Ｅ２缺乏及其所致的ＩＬ６活性升高与绝经后妇女的骨丢失有关，可能参与了绝经后骨质疏松的发病机理。
Toexploretheeffectofseruminterleukin6(IL6)andserumsexualhormoneslevelonthebonelossinwomen,weexaminedtheserumIL6activitybyMTTassay,theserumE2levelwithradioimmunologyanalysisandthebonemineraldensity(BMD)atL24usingDualEnergyXrayAbsorptiometry(DEXA)inyoungwomen,periclimactericwomenandpostmenopausalwomenTheresultsshowedthattheIL6activitywassignificantlyhigherinpostmenopausalwomen,whereastheBMDwassignificantlylowerinpostmenopausalwomencomparedwithyoungwomenandpericlimactericwomen(P<001),theserumE2levelwasalsosignificantlylowerinpostmenopausalwomen(P<001),as compared with other two groups. Moreover,theIL6hadnegativecorrelationwithBMD(r=-0724,p<005),whilenegativecorrelationwithE2(r=-0759,P<001),E2hadpositivecorrelationwithBMD(r=0660,P<001)TheseresultssuggestthatthedecreaseofE2andtheincreasedproductionofIL6wasassociatedwiththebonelossinpostmenopausalwomen,thusindicatingthattheymayberelatedtothepathogenesisofosteoporosis
出处
《上海免疫学杂志》
CSCD
北大核心
1999年第1期35-37,共3页
Shanghai Journal of Immunology
