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DLL4表达水平与浸润性导管癌术后生存率的关系 被引量：3

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摘要 目的研究DLL4(Delta-like4Notch Ligand)在乳腺癌中的表达水平与临床病理特征及预后的关系。方法通过芯片技术及免疫组织化学方法回顾性分析102例具有5年以上临床随访资料的乳腺癌病例中DLL4的表达水平。结果 DLL4在乳腺癌组织中的表达主要位于肿瘤细胞胞浆内。DLL4在乳腺癌组织中的表达水平与乳腺癌患者的临床分期(P<0.01)、淋巴结转移(P<0.05)及预后(P<0.05)相关。Cox多重回归分析显示DLL4表达量为乳腺癌的独立预后因素之一(P<0.05)。结论 DLL4表达水平与乳腺癌患者预后不良有关,其可能是一种潜在的乳腺癌独立预后指标。
作者 吴其年 黄马燕 吴秋良 邵建永 宗永生 符珈 匡亚玲
机构地区 中山大学肿瘤防治中心华南肿瘤学国家重点实验室病理科 中山大学中山医学院病理教研室
出处 《广东医学》 CAS CSCD 北大核心 2010年第11期1441-1443,共3页 Guangdong Medical Journal
关键词 DLL4 浸润性导管癌 预后
分类号 R734.2 [医药卫生—肿瘤]
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参考文献11

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同被引文献45

  • 1Suchting S,Freitas C,le Noble F,et al.The Notch ligand Delta-like 4 negatively regulates endothelial tip cell formation and vessel branching[J].Proc Natl Acad Sci USA,2007,104(9):3225-30.
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引证文献3

二级引证文献11

广东医学
2010年 第11期

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