自体血离体照射回输提高机体抗辐射能力的临床研究

Radioprotective effects of autotransfusion in patients receiving radiotherapy of irradiated blood

目的探讨自体血离体照射回输提高机体抗辐射能力及对机体正常组织的合理防护。方法自１９９６年１月至１９９７年５月对５１４例确诊癌症放疗、化疗的病人，随机分研究组（自体血离体照射回输）、对照组（常规治疗组），观察血疗前后免疫指标、白细胞变化、急、慢性放射性炎症的发生及治疗、癌症疼痛的止痛、生存质量及急性放疗反应与放疗平均剂量关系。结果自体血离体照射回输有提高机体自身免疫功能（体液免疫、细胞免疫），能显著迅速的升高白细胞，防治急、慢性放射性炎症，迅速镇痛及显著提高生存质量的功能。结论自体血离体照射回输提高机体抗辐射能力的原因，可能是细胞免疫及体液免疫水平的提高，使正常组织的耐受量比常规放疗组的耐受量明显提高，放疗、化疗反应明显减少，未对肿瘤组织起保护作用，对正常组织起了较为合理的防护作用。

Objective\ To study the radioprotective effects of autotransfusion in patients receiving radiotherapy with 60 Co γ rays. Methods From January 1996 to May 1997,514 cases of cancer patients having received radiotherapy or chemotherapy were randomized into a study group (receiving autotransfusion of irradiated blood) and a control group (receiving routine treatment).Before and after treatment,parameters observed included immune function,WBC counts,radiation inflammation,pain relieving, survival quality and relationship between acute radiation reaction and mean radiotherapy dose. Results The autotransfusion of irradiated blood enhanced immune function, WBC counts ,relieved pain,improved survival quality and controlled radiation inflammation.Conclusion The reason that the radioprotective effects of autotransfusion of irradiated blood may be attributed to the enhancement of immune function,thereby increasing tolerance to larger than routine radiotherapy doses and reducing effects.It may protect the normal tissues rather than tumor tissues.