泌尿系子宫内膜异位症临床诊治特点分析

Clinical diagnosis and treatment for urinary tract endometriosis

目的 探讨泌尿系子宫内膜异位症的临床诊治特点.方法 女性泌尿系子宫内膜异位症患者10例.平均年龄39（28～49）岁.病史6个月～3年.膀胱子宫内膜异位症4例,临床表现为月经期尿路刺激症、下腹部坠痛不适感,其中伴肉眼血尿1例.B超、CT检查提示膀胱占位病变直径2.0～3.5 cm.输尿管子宫内膜异位症6例,左侧4例,右侧2例.临床表现为腰腹部不适4例,间断无痛性肉眼血尿1例,查体B超偶然发现肾积水1例.B超检查肾盂分离2.0～4.5 cm,输尿管中上段扩张1.0～2.0 cm,其中1例输尿管下端占位伴肾重度积水;CT检查输尿管下段狭窄5例,长度2.0～3.0 cm;输尿管下段占位病变1例.结果 10例均行手术治疗.膀胱部分切除4例,其中同时切除双卵巢、子宫1例;输尿管部分切除输尿管膀胱吻合术3例,输尿管端端吻合术2例,肾输尿管全长切除1例.术后病理诊断均为子宫内膜异位症.术后9例服用17α-乙炔睾丸酮200 mg,2次/d,持续6～12个月.10例患者随访12～60个月,8例恢复良好;2例输尿管子宫内膜异位症患者术后18、24个月复发,予内置输尿管支架管,分别口服17α-乙炔睾丸酮及注射戈舍瑞林治疗3个月后症状缓解.结论 泌尿系子宫内膜异位症多无特异性表现,术前确诊困难,手术切除病灶效果好,辅助药物治疗可预防复发.

Objective To evaluate the diagnosis and treatment of urinary tract endometriosis.Methods Retrospective review of 10 female cases of urinary tract endometriosis was carried out. All cases age was from 28-49, and the average age was 39-year-old. The course of this disease was from 6 months to 3 years. Four of 10 cases were bladder endometriosis. The clinical presentations included the urgency, frequency, pain at micturition and lower abdomen pain during menstruation, gross hematuria coinciding with menstruation 1 case. B-ultrasound and CT showed the mass of bladder from 2. 0 -3.5 cm but were not specific. Four of 6 cases ureteral endometriosis were the left side and 2 cases were the right side. This clinical presentation included non-specific flank or abdomenal discomfort in 4 cases, intermittent gross hematuria in 1 case and 1 case renal hydronephrosis was found incidentally by B-ultrasound. B-ultrasound indicated unilateral upper urinary tract dilation and hydrops in all cases,with pyelic separation from 2.0-4.5 cm and ureteral separation from 1-2 cm. CT indicated stenosis of the lower ureter in 5 cases, ureter tumor in 1 case. Results All cases were treated surgically.Partial cystectomy were performed in 4 cases of bladder endometriosis, of which, 1 case bilateral oophorectomy and hysterectomy. Five cases were performed ureteral segmental resection, of which, 3 ureterocystostomy and 2 terminoterminal anastomosis. 1 case was performed radical nephrectomy and ureterectomy. Postoperative pathological findings confirmed the diagnosis of endometriosis. Postoperative oral hormone therapy was given to 9 cases for 6-12 months. All cases were followed for 12-60months. 2 cases ureteral endometriosis had recurrent hydronephrosis in 18-24 months. The 2 cases received ureteral stent and cured by oral hormone therapy or goserelin subcutaneous injection for 3 months. Conclusions Urinary tract endometriosis usually shows non-specific symptoms. The diagnosis can be missed on both clinical examination and preoperative work-up. Surgical treatment is effective and adjuvant hormone therapy is often recommended to prevent the recurrence.