急性冠脉综合征患者血清P选择素及血小板参数检测的临床意义

Clinical Effect of P-selectin Level and Platelet Parameters in Acute Coronary Syndrome

目的探讨P选择素(P-selectin)和血小板参数在急性冠脉综合征(ACS)患者血清中的变化及临床意义。方法选取ACS患者30例,稳定型心绞痛(SA)患者30例,健康对照者20例。采用酶联免疫吸附试验(ELISA)方法,统一测定血清中P-selectin的水平。同时,测定血小板参数,包括:血小板平均体积(MPV)、血小板分布宽度(PDW)等,运用t检验等统计学方法进行分析。结果 ACS患者P-selectin、MPV、PDW显著高于SA组和对照组,SA组与对照组相比差异无显著性意义。相关分析表明:ACS组P-selectin的浓度变化与MPV、PDW呈正相关。结论 P-selectin的变化是血小板活化较特异的指标,对ACS的判定有重要价值。

Objective To investigate the changes of serum P-selectin level and platelet parameters in acute coronary syndrome（ACS）.Methods 30 cases of ACS,30 cases of stable angina（SA） and 20 cases of normal people were observed.The levels of serum P-selectin were analyzed by ELISA and platelet parameters were collected.Results The levels of P-selectin,mean platelet volume（MPV）and platelet distribution width（PDW）in patients with ACS were higher than those in SA and control group significantly.The level of P-selectin was positively correlated with MPV and PDW.Conclusion The P-selectin is the marker of platelet activation and plays an important role in recognizing ACS.