摘要
目的研究乙酰谷酰胺对戊四氮致痫大鼠大脑病理改变的影响。方法戊四氮腹腔注射建立癫痫模型,每组分别给予不同剂量乙酰谷酰胺治疗,经主动脉灌注取脑组织,HE染色观察大脑病理改变情况。结果治疗组神经元平均坏死率明显低于对照组,差异有统计学意义(P<0.05)结论乙酰谷酰胺对癫痫导致的脑损伤有治疗作用,并且其疗效呈现一定的剂量和治疗时间依赖性。
Objective To investigate the effect of acetylglutamide on pathological changes of rats with seizure induced by pentetrazole.Methods The rats were injected into abdomen with PTZ to induce seizure.Then these rats were separately treated with different dose of acetylglutamide with different days.And next perfuse the rats through aorta to get brain tissues which were fixed and paraffin embedded later.Then observe the pathological changes of the brain by microscope.Results neuron death rate of the treated group was significantly lower than the control group（P〈0.05）.Conclusion acetylglutamide possesses the active effect on epilepsy,and its therapeutic effect correlates with its dosage and therapy time course to some extent.
出处
《黑龙江医学》
2010年第6期420-421,464,共3页
Heilongjiang Medical Journal
关键词
乙酰谷酰胺
戊四氮
致痫
Acetylglutamide
Pentetrazole（PTZ）
Epilepsy
