粤西沿海地区Graves病与尿碘的相关性研究

Correlation of concentrations of iodine in urine with Graves disease along coastal area of western Guangdong

目的探讨广东粤西沿海地区Graves病发病与尿碘的相关性以及正常成年人碘营养状况。方法收取2006年门诊及住院患者中初诊为Graves病(Graves'disease,GD)102例和正常对照组100例,应用砷铈催化分光光度法测定其尿碘含量和用免疫化学发光法测定外周血FT3,FT4,TSH,甲状腺过氧化物酶抗体(TPOAb)和甲状腺球蛋白抗体(TGAb)。结果 GD组尿碘中位数为305.50μg/L,正常对照组尿碘中位数为263.51μg/L,两组比较差异有统计学意义(Z=-2.558,P=0.011);GD组中尿碘在300μg/L以上发生突眼占21%,高于其它各组(P<0.05),TPOAb和TGAb水平同样高于其它各组(χ2=9.567,P=0.023;χ2=8.414,P=0.038)。结论提示湛江沿海地区成人碘摄入量偏高;碘可能诱发GD的发生和加重GD突眼。

Aim To investigate correlation of urinary iodine level with Graves Disease （GD） along coastal area of western Guangdong. Methods The level of the levels of FT3,FT4,TSH,TPOAb,TGAb in urine were measured by immunochemiluminometric assay（ICMA）in 102 GD and 100 healthy subjects. Results The median of iodine in urine was 305.50μg/L in GD patients and 263.51μg/ L in healthy controls. Showing significant difference between two groups（Z=-.558, P=0.011）. The incidence of Graves＇ ophthalmopathy（GO）was 21%when the urine iodine median was over 300 μg/ L in GD patients,which were significantly higher than those of the other three groups （P0.05）The same results could be obtained for TPOAb and TGAb （χ2=9.567,P=0.023;χ2=8.414,P=0.038）. Conclusion The intake of iodine was higher among the population along coastal area in western Guangdong,indicating that iodine might be a risk factor in the pathogenesis of Graves disease. The high iodine intake also may aggravate clinical symptoms such as GO in GD patients.