ACE与醛固酮浓度在房颤消融前后变化及其临床意义

Significance of variations of plasma angiotensin converting enzyme and aldosterone before and after atrial fibrillation catheter radiofrequency ablation

目的观察血管紧张素转换酶(ACE)和醛固酮在房颤导管消融术前、后的变化,探讨其在预测房颤复发的应用价值。方法选择经导管消融术的持续性房颤患者(房颤组)38例,同期选择窦性心律患者38例作为对照组,收集房颤组术前、后,对照组入院第2d血清,测定血清ACE和醛固酮浓度。结果房颤组血清ACE和醛固酮浓度显著高于对照组,经过导管消融术后血清ACE和醛固酮浓度均显著下降,差异有统计学意义(P>0.05)。结论 ACE和醛固酮浓度对于房颤的诊断与评估及在预测导管消融后房颤复发方面有重要的应用价值。

Aim To observe the changes of levles of plasma angiotensin converting enzyme （ACE）and aldosterone before and after atrial fibrillation catheter radiofrequency ablation. Methods There 38 catheter ablation cases were selected as the experimental group and another 38 cases with sinus rhythm as control group. Result Levels of ACE and aldosterone in patients with atrial fibrillation were significantly higher than that of sinus rhythm,levels of ACE and aldosterone were significantly reduced after catheter ablation,showing significant differences （P 0.05）. Conclusion Detection of levels of ACE and aldosterone is valuable for diagnosis and predicting of atrial fibrillation recurrence.