益艾康胶囊治疗HIV/AIDS病人60个月CD_4^+T细胞计数和病毒载量临床观察

Sixty-month clinical observation of HIVcarriers/AIDS patients treated with Yiaikang capsule in terms of theirs CD_4^+T counts and viral loads

目的观察益艾康胶囊对艾滋病病毒(HIV)感染者/艾滋病(AIDS)病人(简称HIV/AIDS病人)CD4+T细胞计数和病毒载量的影响。方法选择1349例HIV/AIDS病人,分为益艾康组口服中成药益艾康胶囊,益艾康+HAART组给予HAART治疗,6个月检测1次CD4+T细胞,1年检测1次病毒载量,连续观察60个月,并对两组进行比较。结果益艾康组434例,口服中成药益艾康胶囊每次5粒,每日3次;益艾康+HAART组治疗915例。治疗60个月后,CD4+T细胞计数两组间差异无统计学意义(P<0.05)。以CD4+T计数升降50个/μl为评定值,益艾康组上升者占28.70%;稳定者占17.10%;益艾康+HAART组上升者占46.80%;稳定者占20.50%,组间比较差异有统计学意义(P=0.00)。118例病毒载量下降程度与疗前相比,两组差异均具有统计学意义(P>0.05)。益艾康组病毒载量下降率为64.10%,下降和稳定共计85.89%;益艾康+HAART组下降率为57.50%,下降和稳定共计90.00%,两组之间比较差异无统计学意义(P>0.05)。结论益艾康胶囊具有提高病人细胞免疫功能或使之保持稳定,并降低或稳定病人病毒载量的作用。

Objective To observe the effect of Yiaikang capsule on CD＋4T cells count and viral loads in the treated HIV carriers/ AIDS patients. Method A total of 1349 HIV carriers/AIDS patients were selected,and 434 were placed in the Yiaikang group,which took orally Yiaikang capsule 3 times a day and 5 pills one time,while 915 were placed in the group with Yiaikang plus ARV drugs. The CD＋4T count was detected twice a year,and the viral load was detected once a year. The paticipants were continuously treated for 5 years. Result After 5 year therapy,the difference in CD＋4T count between the two groups was not significant. Taking the increase or decrease of CD＋4T count per 50/μl as a cut off point,28.7% of the participants in the Yiaikang group had an increased CD＋4T count and 17.10% had a stable one while 46.80% of the participants in the group with Yiaikang plus ARV drugs had an increased CD＋4T count and 20.50% had a stable one,and there was significant difference between the two groups. The difference in viral loads before and after the therapy was significant. In the Yiaikang group,the descending rate of viral loads was 64.10%,and the descending and stable viral loads accounted for 85.89% altogether; in the group with Yiaikang plus ARV drugs,the descending rate of viral loads was 57.50%,and the descending and stable viral loads accounted for 90.00% altogether. But difference in the viral loads between the two groups was not significant. Conclusion The therapy with Yiaikang capsule could decrease or stabilize the patients＇ viral loads,and could increase the patients＇ immunity and make it stable.