尿液标本培养中大肠埃希菌的耐药性分析

Drug resistance analysis of Escherichia coli from urine specimen

目的了解本院2008～2009年临床尿培养标本中分离的大肠埃希菌对各类抗生素的耐药性。方法收集2008～2009年本院临床尿培养标本中分离的大肠埃希菌株,按统一的方法和判断标准进行大肠埃希菌的药敏试验和超广谱β-内酰胺酶(ESBLs)检测的确认试验。结果尿液标本分离出大肠埃希菌416株,对哌拉西林/他唑巴坦、呋喃妥因的敏感率较高,未发现对亚胺培南耐药菌株。结论大肠埃希菌为泌尿系感染的常见致病菌,治疗时应尽量根据细菌药敏试验结果调整抗生素。

Objective To investigate the antibiotic resistance of Escherichia coli collected from urine specimen in 2008~2009.Methods All Escherichia coli strains were isolated from urine specimen during the period from Jan.2008 to Dec.2009 in our hospital.Susceptibility testing was carried out by means of a unified protocol method and the results were analyzed according to CLSI2005 standard.At the same time the affirmed test of the ESBLs was carried out.Results The total 416 strains of E.coil were isolated from urine specimen.The sensitivity to piperacillin-tazobactam sodium and nitrofurantoin was high.The strain resistant to imipenemt was not found.Conclusion Escherichia coli is commonly seen in urinary tract infection.Antimicrobial therapy should be initiated under the guidance of antimicrobial sensitivity test if possible.