住院患者药源性肾损害的原因分析及预防

Analysis of drug-induced renal injury in inpatients

目的 分析我院住院患者发生药源性肾损害的情况,以指导合理用药.方法 对我院2006年6月至2008年10月间肾损害328例住院患者的临床资料进行回顾性分析,分析肾损害的原因.结果 有62例患者出现药源性肾损害（占18.9%）,药物包括抗生素、脱水药、血管紧张素转换酶抑制剂等.2例患者因大剂量服用复方新诺明,2例因大剂量静脉注射甘露醇,1例患者使用丁胺卡那酶素超过10 d而出现肾损害.结论 剂量过大、疗程过长是用药后出现肾损害最主要的原因,应合理用药,避免药源性肾病的发生.

Objective To investigate the drug-induced renal injury of inpatients to provide information for rational use of drugs. Methods A retrospective analysis was performed in 328 cases whose blood Cr level was abnormal from June in 2006 to October in 2008. Results Of the 328 cases, 62 patients （ 18.9 % ） suffered from drug-induced renal injury induced by drugs including antibiotics, dehydrants ACEI and so on. Conclusion To avoid drug-induced renal function injury, medication should be carried out by strictly following indications and the dosage and administration stated in the drug package insert.