根除HP治疗在十二指肠溃疡治疗中的作用临床观察

The Investigation of the Function on the Duodenal Ulcer of Eradicative Treatment of Helicobacter Pylori (HP)

目的:探讨抗幽门螺杆菌(Helicobacter Pylori,HP)对治疗十二指肠溃疡的疗效及预后的影响。方法:选取2006年9月—2008年12月在我院消化科住院及门诊治疗的56名幽门螺杆菌阳性的十二指肠溃疡活动期患者,随机分为两组。对照组予常规抑酸保护粘膜治疗;观察组在常规抑酸保护粘膜治疗基础上行抗Hp治疗。观察腹痛缓解率、溃疡愈合率及1年后复发率等方面的差异。结果:观察组D1和D3疼痛缓解率分别为43%和62.5%,与对照组的41.7%和61.2%无统计学差异(P>0.05);6周后复查胃镜溃疡愈合率,观察组为96.7%,明显高于对照组的88.5%,具有统计学差异(P<0.05);观察组1年后复发率为9.1%,明显低于对照组的44.6%(P<0.05)。结论:抗HP治疗能够更好地促进十二指肠溃疡的愈合及防止十二指肠溃疡的复发。

Aim：To discuss the influence of eradicative treatment of Helicobacter Pylori（HP） on the treatment and prognosis of duodenal ulcer.Methods： This research classified 56 HP positive patients who were during the active time of duodenal ulcer acsecess into 2 groups randomly.Comparison group： regular treatment of anti-acid protection velum;observation group： eradicative treatment of HP based on regular treatment of anti-acid protection velum.To observe the discrepencies of bellyache catabatic rate,abscess cicatrization rate and recrudeesce rate after a year etc.Results：The bellyache catabatic rates of D1 and D3 in observation group were 43% and 62.5% respectively,which showed no statistical discrepancy with comparison group＇s 41.7% and 61.2%.（P0.05）;6 weeks later,when rechecked the gastroscope abscess cicatrization rate,observation group（96.7%） which was remarkably higher than comparison group（88.5%）,which showed a statistical discrepancy（P0.05）;recrudeesce rate after a year of observation group（9.1%） was remarkably lower than that of comparison group（44.6%）（P0.05）.Conclusions：The eradicative treatment of Helicobacter Pylori（HP） could positively promote the cicatrization of duodenum ball acsecess and effectively prevent recrudeesce.