微量元素硒对梗阻性黄疸肝脏细胞保护作用的观察

Trace Element Selenium to Obstruction Jaundice Liver Cytoprotection Research

目的探讨微量元素硒对肝脏细胞的保护作用。方法用大鼠制成梗阻性黄疸动物模型,通过生化检测和电镜观察补硒大鼠肝脏功能变化和肝细胞超微结构改变。结果微量元素硒能明显降低梗阻性黄疸大鼠血清谷丙转氨酶、总胆红素及直接胆红素(P<0.01),减轻肝细胞超微结构的损伤。结论微量元素硒对梗阻性黄疸肝细胞的结构和功能存在一定的保护作用,是一种具有应用前途的肝细胞保护剂。

Objective To investigate the selenium protective effect on liver cells.Methods Rat animal model of obstructive jaundice produced by bio-chemical tests and election microscopy of Se changes in liver function and liver cell ultrastructure.ResultsThe trace element selenium significantly reduced in rats with obstruction alanine aminotransferase,total bilirubin and direct biliurbin（P〈0.01）,to reduce liver cells in obstructive jaundice.Conclusions There is a certain structure and function of the protective effect is a kind of application of the future liver protective agent.