期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

MMP9、VEGF、NACM、Ki67在胶质瘤组织表达与其复发的关系 被引量：3

MMP9,VEGF,NACM,Ki67 expression in gliomas and its recurrence
下载PDF
导出
摘要 目的:探讨基质金属蛋白酶9(MMP9)、血管内皮细胞生长因子(VEGF)、神经细胞黏附分子(NACM)、核增殖抗原表达基因(Ki67)在胶质瘤组织中的表达及其与胶质瘤复发的关系。方法:用免疫组织化学方法检测20例正常脑组织和76例胶质瘤复发脑组织中MMP9、VEGF、NACM、Ki67的表达,并对胶质瘤复发进行分析。结果:胶质瘤复发与Ki67和MMP9表达有关(P<0.05),而其他生物学指标的表达与其复发无显著关系。结论:Ki67和MMP9的阳性表达可以作为评价胶质瘤复发的生物学指标。 Objective：To investigate MMP9,VEGF,NACM,Ki67 expression in glioma tissues and relationship with recurrent glioma.Methods：Immunohistochemistry was used to detect 20 cases of normal brain tissue and 76 cases of recurrent glioma tissues MMP9,VEGF,NACM,Ki67 expression,and analyzed with glioma recurrence.Results：Ki67 and MMP9 in patients with recurrent glioma expression（P〈0.05）,while the expression of other biological indicators of recurrence with no significant relationship.Conclusion：Ki67 and MMP9 expression evaluation can be used as biological indicators of recurrent glioma.
作者 张永哲 郑永日 王建交
机构地区 哈尔滨医科大学附属第二医院神经外二科
出处 《中国当代医药》 2010年第17期5-6,共2页 China Modern Medicine
关键词 胶质瘤 基质金属蛋白酶9 血管内皮细胞生长因子 神经细胞黏附分子 核增殖抗原表达基因 Glioma MMP9 VEGF NACM Ki67
分类号 R739.4 [医药卫生—肿瘤]
  • 相关文献

参考文献5

二级参考文献65

  • 1[1]Hynes RO.Integrins: versatility, modulation, and signaling in cell adhesion[J].Cell,1992,69(1):11-25.
  • 2[2]Uhm JH, Gladson CL, Rao JS. The role of integrins in the malignant phenotype of gliomas[J].Front Biosci ,1999,4(2): 188-199.
  • 3[3]Paulus W, Baur I, Schuppan D et al. Characterization of integrin receptors in normal and neoplastic human brain[J]. Am J Pathol,1993,143(1):154-163 .
  • 4[4]Tonn JC, Wunderlich S, Kerkau S et al. Invasive behaviour of human gliomas is mediated by interindividually different integrin patterns[J]. Anticancer Res,1998,18(4):2599-2605.
  • 5[5]Giese A, Laube B, Zapf S, et al.Glioma cell adhesion and migration on human brain sections[J]. Anticancer Res,1998,18(3):2435-2447.
  • 6[6]Rooprai HK, Vanmeter T, Panou C, et al。The role of integrin receptors in aspects of glioma invasion in vitro[J]. Int J Dev Neurosci. 1999,17(5-6):613-623.
  • 7[1]Sven JT, Nygaard Hans KR, Laerum H, et al. Dynamic determination of human glioma invasion in vitro[J]. J Neurosurg,1998,89 (3): 441-447.
  • 8[2]Hill JR, Kuriyama N, Kuriyama H, et al. Molecular Genetics of brain tumors[J]. Arch Neurol,1999,56(3):439-441.
  • 9[3]Wang K, Gan L, Jeffery E, et al. Monitoring gene expression profile changes in ovarian carcinomas using cDNA microarray[J]. Gene, 1999,229(1): 101-108.
  • 10[4]Schena M, Shalon D, Dais RW, et al. Quantitative monitoring of gene expression patterns with a complementary DNA microarray[J]. Science,1995, 270 (20):467-470.

共引文献25

同被引文献21

  • 1赵启中,吴安华,郭宗泽,王运杰.p53和Survivin在低级别复发胶质瘤中的表达及相关性[J].中国医科大学学报,2005,34(2):171-172. 被引量：2
  • 2Tokunaga T,Oshika Y,Abe Y,et al.Vascular endothelial growth factor (VEGF) mRNA isoform expression pattern is correlated with liver metastasis and poor prognosis in colon cancer[J].Br J Cancer,1998,77(6): 998-1002.
  • 3Kleihues P, Webster K, Cavenee W. Pathology and genetics of tumours of the nervous system [ J ]. International Agency for Research on Cancer,2006,6( 1 ) :61-66.
  • 4Klepper Lia. Method of calculating the equivalent tumor dose as a function as to irradiated tumor tissue volume [ J ]. MedTekh, 2001, (4) :15-20.
  • 5Semenza GL,Agani F,Booth G,et al. Structural and functional analysis of hypoxia-inducible factor 1 [ J ]. Kidney Int, 1997,51 ( 2 ) : 553 -555.
  • 6Sondergaard KL, Hilton DA, PenneyM, et al. Expression of hypoxia- inducible factor lalpha in tumours of patients with glioblastom[ J]. Neuropathol Appl Neurobio1,2002,28 ( 3 ) :2 I0-217.
  • 7Jacqueline Kessler,Antje Hahnel, et al. HIF-1 cdnhibition by siRNA or chetomin in human malignant glioma cells:effects on hypoxic radioresistance and monitoring via CA9 expression [ J ]. BMC cancer 2010,10:605.
  • 8Villapol S, Acarin L, Faiz M, et al. Survivin and heat shock protein 25/27 colocalize with cleaved caspase-3 in surviving reactive astrocytes following excitotoxicity to the immature brain [ J ]. Neuro- science ,2008,153 ( 1 ) : 108-119.
  • 9Wang M, Liu S,, et al. The expression of matrix metalloproteinase-2 and -9 in human gliomas of different pathological grades[J]. Brain Tumor Pathol,2003,20 ( 2 ) :65-72.
  • 10Jae Young Choi, Yeon Soo Jang, et al. Overexpression of MMP-9 and HIF-1α in Breast Cancer Cells under Hypoxic Conditions [ J ]. J Breast Cancer,2011,14(2) : 88 - 95.

引证文献3

二级引证文献6

中国当代医药
2010年 第17期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部