血清和胃液中多种肿瘤标志物检测在胃癌中的临床价值

The clinical value of the test of serum and gastric juice TNF-α,CEA,CA199 and CA724 in the patients with gastric cancer

目的:探讨血清和胃液中多种肿瘤标志物检测在胃癌中的临床价值。方法:选取2008年12月～2009年12月于本院进行治疗的35例胃癌患者为A组,同时选取同期的35例良性胃病患者为B组和35名健康人为C组,后将3组人员的血清及胃液人肿瘤坏死因子α(TNF-α)、癌胚抗原(CEA)、糖类抗原199(CA199)和糖类抗原724(CA724)中的水平进行检测及比较。结果:经研究比较发现,A组的血清及胃液TNF-α、CEA、CA199和CA724水平明显高于B组及C组,P<0.05或P<0.01,差异均有统计学意义。且晚期胃癌患者的血清及胃液TNF-α、CEA、CA199和CA724水平明显高于早期患者,胃液明显高于血清,P均<0.05。结论:在胃癌的诊断中采用血清及胃液TNF-α、CEA、CA199和CA724联合检测对于提高检测率有重要作用。

Objective：To study the clinical value of the test of serum and gastric juice TNF-α,CEA,CA199 and CA724 in the patients with gastric cancer.Methods：35 cases patients with gastric cancer in our hospital from December 2008 to December 2009 were selected as group A,and 35 cases contemporaneous patients with benign gastric disorders were select ed as group B and 35 healthy people were selected as group C.Then the serum and gastric juice TNF-α,CEA,CA199 and CA724 of the three groups were tested and compared.Results：The levels of serum and gastric juice TNF-α,CEA,CA199 and CA724 were higher than those of group B and group C,P〈0.05 or P〈0.01,all differences had statistical significance.And the levels of serum and gastric juice TNF-α,CEA,CA199 and CA724 of advanced gastric cancer were higher than those of early gastric cancer,and the levels of gastric juice TNF-α,CEA,CA199 and CA724 were higher than those of serum,P〈0.05.Conclusion：The detection of serum and gastric juice TNF-α,CEA,CA199 and CA724 in the patients with gastric cancer is valuable for increasing detection rate.