肺炎支原体感染导致支气管哮喘的机制探讨

Study on Mechanism of Mycoplasma Pneumoniae Infection Resulting in Bronchial Asthma

肺炎支原体(MP)作为非典型病原体,其感染发病率在哮喘患儿中有逐年增高的趋势。MP感染直接损伤上皮细胞,影响细胞因子、炎性介质及IgE的释放,调节黏液分泌,引起呼吸道慢性变应性炎性反应,同时可引起呼吸道平滑肌收缩过强,腺体分泌增加,导致呼吸道高反应。此外,MP能引起细胞免疫和体液免疫的缺陷,导致免疫功能失调。

The infection with mycoplasma pneumoniae as atypical pathogen has become increased in patients with asthma. Mycoplasma pneumoniae that attaches to airway epithelial cells can cause cell damage,influence cytokine,IgE release and mucus secretion,at the same time,it can result in the chronic inflammation,bronchial smooth excessive contraction,mucous glands hypersecretion and airway hyperreactivity in respiratory tract. In addition,children with asthma have deficient cellular and humoral responses to mycoplasma pneumoniae infection,resulting in immunity disorder.