脑钠素和C反应蛋白在急性心肌梗死患者中的应用

Use of Brain Natriuretic Peptide and C-Reactive Protein in Acute Myocardial Infarction

目的探讨脑钠素(BNP)、C反应蛋白(CRP)在急性心肌梗死(AMI)患者中的变化及临床意义。方法观察126例AMI患者BNP、CRP水平,并与40例健康组对照,比较两组的差异。随访患者住院期间、28d主要心脏不良事件(MACE)(心源性死亡、再次心肌梗死、反复再发心绞痛、心力衰竭和再入院的复合终点)的发生情况,并比较BNP和CRP水平与MACE的关系。结果 AMI组的BNP、CRP水平显著高于对照组(P<0.01);AMI患者MACE组较非MACE组的BNP、CRP水平显著升高(P<0.01)。结论 AMI患者的BNP和CRP水平对AMI患者的诊断、病情评估具有一定的临床意义。

Objective To study the value of brain natriuretic peptide（ BNP） and C-reactive pro- tein（ CRP） in acute myocardial infarction. Methods The levels of BNP and CRP were measured in 126 patients with AMI and 40 healthy controls. The difference was compared between two groups. The mortality and the risks of major adverse cardiac events（ including the composite end point of death,recurrent myocardial infarction,angina pectoris,heart failure,and re-hospitalization） at 28 d were analyzed. The correlation of BNP and CRP levels with MACE was compared. Results The levels of BNP and CRP in AMI group were significantly higher than control group（ P 0. 01） . The levels of BNP and CRP in AMI patients of MACE group were significantly higher than those in non-MACE group （ P 0.01） . Conclusion The levels of BNP and CRP had a certain clinical significance on diagno- sis,prognosis and assessment of AMI patients.