镍钛合金支架置入治疗恶性肿瘤致中心气道狭窄引起的呼吸困难

Domestic nitinol stent implantation to treat dyspnea due to central airway stenosis caused by malignant tumors

目的探讨应用国产镍钛合金支架置入治疗恶性肿瘤所致中心气道狭窄引起的呼吸困难的临床疗效。方法恶性肿瘤致中心气道狭窄为原因的呼吸困难患者12例,经支气管镜引导辅助置入镍钛合金支架,治疗前后血气分析、Karnofskyi评分法(KPS)评分值、支气管镜和影像学表现进行比较,以观察疗效。结果 12例患者支架均放置成功,中心气道狭窄明显扩张,呼吸困难、活动受限显著改善,术后动脉血氧分压、KPS评分值较术前明显提高,无严重并发症和死亡。结论支气管镜引导辅助国产镍钛合金支架置入对恶性肿瘤致中心气道狭窄引起的急性呼吸困难是一种有效、安全、微创的姑息性治疗方法 ,短期疗效明显,挽救了患者生命,提高了生活质量,为其进一步治疗创造了机会。

Objective To investigate the application efficacy of implantation of domestic nitinol stent for the treatment of dyspnea induced by central airway stenosis caused by malignant tumors. Methods Twelve patients with dyspnea due to central airway stenosis caused by malignant tumor with bronchoscopy-assisted implantation of nitinol stents,blood gas analysis,KPS score value,bronchoscopy and radiologic imaging before and after treatment compared to observe the therapeutic effects. Results Twelve patients,stents were placed su-ccessfully,a remarkable expansion of central airway stenosis,dyspnea and limitation of activity markedly relieve,compared with preoperative and postoperative PaO2,KPS score were significantly improved,no severe complications and death. Conclusion Bronchoscope-assisted implantation of domestic nitinol stents for the treatment of dyspnea induced by central airway stenosis caused by malignant tumors is a effective and safe minimally invasive palliative treatment,saving lives of patients in the short term,significantly improve patient quality of life and create opportunities for further treatment.