浙南地区人群ApoB、ApoE等位基因频率的初步研究

THE FREQUENCY OF APOLIPOPROTEIN B, E ALLELES IN SOUTHERN ZHEJAING

为了研究ＡｐｏＢ、ＡｐｏＥ等位基因在浙南地区人群中的频率分布，我们应用ＰＣＲＲＦＬＰｓ 检测了浙南地区６０ 例无脂代谢紊乱的健康人ＡｐｏＢ的多态性位点ＸｂａⅠ、ＥｃｏＲⅠ，ＡｐｏＥ的ＨｈａⅠ位点的多态性分布。结果发现ＡｐｏＢ的ＸｂａⅠ、ＥｃｏＲⅠ酶切位点以Ｘ－ 和Ｅ＋ 等位基因占优势，频率分别为０ ．９８３ 和０ ．９６７ ，Ｘ＋ 和Ｅ－ 等位基因很少见。ＡｐｏＥ 等位基因频率分布为：Ｅ２ ＝０．０２，Ｅ３＝ ０ ．８６ ，Ｅ４ ＝０ ．１２ 。

To study the frequency of ApoB\, ApoE alleles in population of Southern Zhejiang, we collected 60 random healthy individuals to detect the polymorphic sites EcoRⅠ\, XbaⅠ of ApoB. Hha Ⅰ of ApoE by PCR RFLPs. The result showed X\+- allele and E\++ allele of XbaⅠ and EcoRⅠ restriction sites of ApoB have an advantage in frequencies of alleles having relative frequency of 0.983 and 0.967, respectively. X\++ and E\+- alleles were very rare. The frequencies of the three ApoE alleles were E2=0.02, E3=0.86, E4=0.12.