表皮生长因子受体在回盲部癌组织中的表达及临床意义

Expression of Epidermal Growth Factor Receptor in Ileocecal Cancer and its Clinical Implications

目的研究人表皮生长因子受体（epidermal growth factor receptor, EGFR）在回盲部癌组织中的表达，分析其表达与患者临床病理学指标的预后意义以及和生存率之间的关系。方法选取长海医院39例回盲部癌组织，应用免疫组化法对回盲部肿瘤组织石蜡切片中EGFR的表达情况进行检测，结合临床病理指标进行影响生存率因素分析。结果39例回盲部肿瘤EGFR阳性表达率为53.85%（21/39）,T2～T4期肿瘤EGFR阳性表达明显多于T1（P＜0.05），组织分化差、淋巴结和远处转移的肿瘤，EGFR表达高于分化好、无淋巴结和远处转移者（P＜0.05）；EGFR表达与患者性别、年龄、肿瘤原发部位、肿瘤大小、肿瘤分化程度等均无明显相关性。EGFR阴性表达者平均生存时间要长于EGFR阳性表达者（P〈0.05）。结论回盲部癌组织中EGFR表达与患者的预后有一定的关系，阳性表达的患者其预后不良。

ObjectiveTo study the expression of epidermal growth factor receptor （EGFR） in ileocecal cancer and the association with clinicopathological factors influencing the prognosis and overall survival （OS）. MethodsSurgery specimens of 39 patients were pathologically confirmed to be ileocecal cancer. Formalin-fixed and paraffin embedded sections were tested for expression of EGFR by immunohistochemical staining. OS was correlated with several clinicopathological factors and expression of EGFR. ResultsIt was found that EGFR was expressed in 53.85% （21/39）.Tumors in stage of T2 to T4 had significantly higher expression of EGFR as compared with those of T1 tumors （P〈0.05）. EGFR expression in patients with lymphatic and distant metastasis was significantly higher than that without lymphatic or distant metastasis （both P〈0.05）. No relationship was found between EGFR expression and patients′ age, gender and histologic type. A significantly poorer OS was seen in patients with positive EGFR than with negative expression（P〈0.05）. Conclusion It suggested that EGFR status played a significant role in prognosis of ileocecal cancer patients. The patients with positive EGFR expression had poorer OS comparing with those without EGFR expression.