卡培他滨联合支气管动脉化疗治疗结肠癌术后单纯肺转移疗效观察

The Clinical Research of Bronchial Arterial Infusion (BAI) Combined with Capectiabine in the Treatment of Metastatic Lung Tumor after Resection of Colorectal Cancer

目的探讨卡培他滨联合支气管动脉化疗治疗结肠癌肺转移的临床疗效,以期寻找晚期结肠癌理想的治疗方法。方法结肠癌肺转移病例82例,均经病理证实,分为支气管动脉灌注化疗联合卡培他滨组与卡培他滨化疗组。结果支气管动脉灌注化疗联合卡培他滨组和卡培他滨组近期疗效有效率为36.8%和29.5%,半年、1年、2年生存率分别为100%、76.3%、36.8%和90.9%、59.1%、36.3%,前两项组间差异有统计学意义(P<0.05),2年生存率无明显差异(P>0.05)。结论支气管动脉灌注化疗联合卡培他滨是治疗结肠癌肺转移的有效方法,与单用卡培他滨比较,能更有效地控制肺内转移病灶,延长患者的生存期。

ObjectiveTo study the effect of combined bronchial arterial infusion （BAI）with capectiabine chemotherapy in metastatic lung tumor from colorectal cancer,and find a better way to treat the late colorectal cancer. MethodsEighty-two patients with metastatic lung tumor from colorectal cancer were randomly treated by BAI plus capectiabine group or capectiabine group. ResultsThe response rate of primary lesion in BAI plus capectiabine group and capectiabine group were 36. 8% and 29.5%, The survival rate at 6,12 and 24 months were 100%, 76.3%, 36.8% and 90.9%, 59.1%, 36.3%,respectively. They were different between the two groups（P〈0.05）in the first two.However there was no difference in the survival rate of 24 months （P〈0.05）.ConclusionBAI is one of the most effective therapies for the treatment of metastatic lung tumor from colorectal cancer and it can prolong patients′ survival time. Compared with capectiabine group, BAI combined capectiabine has better effect in control metastatic lung lesions.