婴儿利什曼原虫实验感染草原兔尾鼠的进一步观察

A Further Investigation on Infection Experiment of Lagorus lagorus by Leishmania infantum

给草原兔尾鼠（Laguruslagurus）经腹腔接种不同量的婴儿利什曼原虫（Leishmaniainfantum）前鞭毛体，结果表明，不同量的原虫感染对动物体重及肝重没有明显的影响，但脾重则有一定的差异。肝脏原虫负荷随感染虫量的增加而加大，实验结果进一步证明草原兔尾鼠是一种对利什曼原虫非常敏感的实验动物；同时在用级差较小的不同量的原虫接种后，可以显示感染程度的差别，这就为利什曼病的免疫学研究提供了良好的动物模型。

Lagurus lagurus were given experimental intraperitoneal inoculation by promastigotes of L. infantum in different doses. The results showed that there was no relationship between the change of body and liver weights and the numbers, except for spleen of the animals. The more amount of premastigotes were inoculated, the more parasite loads were observed in the livers. It suggested that the Lagurus lagurus was so sensitive to Leishmania that it would be an excellent animal model for immunological research of leishmaniasis.