帕金森病的协同治疗

SYNERGIC TREATMENT OF PARKINSON’S DISEASE

目的：探讨目前帕金森病（ＰＤ）治疗的策略问题。方法：总结分析ＰＤ的药物和手术治疗的最新进展、疗效、适应证及其存在的问题。结果：药物治疗并不能控制所有的ＰＤ症状，且疗效逐渐衰减，特别是伴随长期使用左旋多巴而出现的异动症和“开、关”波动现象，具有与ＰＤ本身症状同样严重的致残性；苍白球腹后部切开术对ＰＤ各种症状及其医源性并发症具有全面、稳定的治疗效果。结论：药物与手术有协同作用。发挥药物的最大功效，外科治疗药物的不足并从根本上消除或缓解药物治疗的不良反应。

OBJECTIVE:The therapeutic strategy for Parkinson's disease(PD)was explored.METHODS:The latest progresses,efficacy,indications,and problems of drugs and surgeries for treatment of PD were reviewed and analyzed.RESULTS:Not all symptoms could be controlled by drug therapy and its efficacy was gradually decreased during continuous medication and its ADRs such as dyskinesia and “on & off”may also cause disablement.Posteroventral pallidotomy can abolish all Parkinson’s symptoms including pharmaceutical complications.CONCLUSION:Combination therapy of drug and surgery are current strategy for treatment of PD,for the drug efficacy could be maximally bring into play and its ADRs,especially L dopa induced ADRs,could be eliminated by surgery.