利培酮与氯丙嗪治疗精神分裂症的对照研究

A CONTROLLED COMPARATIVE STUDY ON RISPERIDONE AND CHLORPROMAZINE IN TREATMENT OF SCHIZOPHRENIA

目的：了解利培酮、氯丙嗪治疗精神分裂症患者的疗效及不良反应。方法：将精神分裂症患者４１例随机分成２组，２１例予利培酮４～６ｍｇ／ｄ，ｐｏ治疗，２０例予氯丙嗪３５０～６００ｍｇ／ｄ，ｐｏ治疗，８周后进行对照研究。结果：利培酮、氯丙嗪组治疗总有效率分别为７３．３％，８０％，２组疗效差别无显著意义（Ｐ＞０．０５），利培酮不良反应小（Ｐ＜０．０５）。结论：两药对精神分裂症阳性症状均有效，在治疗阴性症状上利培酮优于氯丙嗪，提示利培酮治疗精神分裂症阳性、阴性症状均有较好的疗效。

OBJECTIVE:To compare the efficacy and ADRs of risperidone and chlorpromazine in treatment of schizophrenia.METHODS:41 patients with schizophrenia were randomly divided to receive risperidone( n =21) in a dose of 4～6 mg/d for 8 weeks or chlorpromazine( n =20)in a dose of 350～600 mg/d for 8 weeks.RESULTS:The total response rates of risperidone and chlorpromazine groups were 73.3% and 80% respectively.There were fewer ADRs in risperidone group.CONCLUSION:Both drugs are effective in treatment of positive and negative schizophrenia.Risperidone is better than chlorpromazine in treatment of negative schizophrenia.