CD4^+ CD25^+调节性T细胞与卵巢癌的相关性研究

Study on correlation between CD4^+ CD25^+ regulatory T cells and ovarian cancer

目的:探讨卵巢癌患者病灶间质中及上皮内CD3+TILs、CD4+TILs、CD8+TILs、Treg的分布特点。方法:采用免疫组织化学方法检测40例卵巢癌患者病灶间质中及上皮内CD3+TILs、CD4+TILs、CD8+TILs、Treg的表达情况及10例正常卵巢组织中CD3+T细胞、CD4+T细胞、CD8+T细胞、Treg的表达情况。结果:卵巢癌组织中CD3+T细胞、CD4+T细胞、CD8+T细胞数量与正常卵巢组织中相比显著增加,且卵巢癌组织上皮内Treg数量增加。结论:卵巢癌局部微环境中机体对肿瘤抗原可以产生免疫反应,但Treg的存在而抑制了肿瘤的特异性免疫。

Objective：To explore the distribution characteristics of CD3^＋TILs,CD4^＋TILs,CD8^＋TILs and Treg in stroma and epithelium of cases with ovarian cancer.Methods：The expression levels of CD3^＋TILs,CD4^＋TILs,CD8^＋TILs and regulatory T Cells（Treg） in stroma and epithelium of 40 cases with ovarian cancer and expression levels of CD3^＋T cells,CD4^＋T cells,CD8^＋T cells and Treg in normal ovarian tissues of 10 healthy cases were detected by immunohistochemical method.Results：Compared to normal ovarian tissues,the amounts of CD3^＋T cells,CD4^＋T cells and CD8^＋T cells in ovarian cancer increased significantly,and the expression level of Treg in epithelium of ovarian cancer increased.Conclusion：The organ can produce immunology reaction to tumor antigen in ovarian cancer local microenvironment,but Treg restrains this kind of tumor specific immunology.